Pregnancy / Childbirth

DNA of the fetus in the mother's brain? It is possible!

DNA of the fetus in the mother's brain? It is possible!


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American scientists have found that fetal cells can not only pass through the placenta with blood, but also concentrate in the mother's brain for decades. Researchers have proved that mothers who give birth do not quite "lose" all "foreign" cells from their bodies.

Cells can migrate between the body of the mother and the fetus, settling in many organs, including the lungs, thyroid, muscles, liver, heart, kidneys, and skin.

It's not everything. Scientists were able to determine from experiments carried out on rats that these cells could have huge impact in the disease prevention process: also cancer (breast cancer) and can have a beneficial effect on mother's immunity, allowing inflammation to be removed in the body and speeding up recovery. This is because fetal cells have the properties of stem cells and can become part of any tissue.
Researchers at Fred Hutchinson Cancer Research Center analyzed the autopsy results of 59 brains of women aged 32 to 101 years. 63% of them contained male DNA. The oldest brain with such genes has been tested since you were 94 years old.

Microchimerism - meaning everyone has something of their ancestors in them?

Microchimerism translates as the presence of a small number of cells from another individual in the body of another person. Pregnancy is conducive to microchimerism, since during it cells and genetic material are exchanged between mother and fetus through the placenta.

Some studies have proved long-term persistence of fetal DNA cells in the mother's body. Interestingly, mother cells in a small amount are also preserved in healthy children also in their adult life.

Microchimeric cells remain in the bone marrow. They are able to divide and migrate to various organs for many years after delivery. They were found in various organs (kidneys, heart, lungs - organs often transplanted, women with a male offspring).

In the light of new, revolutionary evidence presented by scientists from Seattle and published in PlosOne, the saying "to be an apple's eye" takes on a whole new meaning, just like the huge attachment of parent to child and toddler to parent understood as a sense of unity or belonging.

Bibliography
1. van Rood JJ, Claas F (2000) Both self and non-inherited maternal HLA antigens influence the immune response. Immunol Today 21: 269-273.2. Reed W, Lee TH, Norris PJ et al. (2007). Transfusion-associated microchimerism: a new complication of blood transfusions in severely injured patients. Semin Hematol. 44 (1): 24-31. doi: 10.1053 / j.seminhematol.2006.09.012. PMID 17198844.3. Koopmans M, Kremer Hovinga IC, Baelde HJ et al. (2005) Chimerism in kidneys, livers and hearts of normal women: implications for transplantation studies. Am J Transplant 5: 1495-1502.4. Koopmans M, Kremer Hovinga IC, Baelde HJ et al. (2008) Chimerism occurs in thyroid, lung, skin and lymph nodes of women with sons. J Reprod Immunol 78: 68-75.5. Feitsma AL, Worthington J, van der Helm-van Mil AHM et al. (2007) Protective effect of noninherited maternal HLA-DR antigens on rheumatoid arthritis development. Proc Natl Acad Sci U S A 104: 19966-19970.6. Gammill HS, Adams Waldorf KM, Aydelotte TM et al. Pregnancy, microchimerism, and the maternal grandmother. PLoS One. 2011; 6 (8): e24101. Epub 2011 Aug 30.7. Fugazzola L, Cirello V, Beck-Peccoz P (2011) Fetal microchimerism as an explanation of disease. Nat Rev Endocrinol 7: 89-97. 8.Chan WF, Gurnot C, Montine TJ et al. Male microchimerism in the human female brain ... PLoS One. 2012; 7 (9): e45592. doi: 10.1371 / journal.pone.0045592. Epub 2012 Sep 26.9.Lo YM, Lau TK, Chan LY et al. (2000) Quantitative analysis of the bidirectional fetomaternal transfer of nucleated cells and plasma DNA. Clin Chem 46: 1301-1309.